Synthesis And Characterisation Of Piperine-loaded Starch Nanoparticles
Article Sidebar
Main Article Content
Abstract
This study aimed to explore the potential application of starch
nanoparticles as the nanocarriers for the controlled release of piperine. Starch nanoparticles with mean particle sizes ranging from 50 nm to 200 nm have been synthesised as nanocarriers for encapsulation of piperine. Piperine has been successfully loaded onto starch nanoparticles via the in-situ nanoprecipitation method. The loading capacity of piperine was affected by the synthesis conditions such as types and concentrations of surfactants as well as initial piperine concentrations. Under optimum conditions, starch
nanoparticles exhibited a maximum piperine loading capacity of 4.74 mg mg-1. Piperine was observed to release out from starch nanoparticles in a slow and steady manner over a period of 168 h under physiological pH.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Gogani, L. et al. (2016). Piperine – The bioactive compound of black pepper: From
isolation to medicinal formulations. Comp. Rev. Food Sci. Food Saf., 16(1), 124– 140. https://doi.org/10.1111/1541-4337.12246
Chinta, G. et al. (2015). Piperine: A comprehensive review of pre-clinical and
clinical investigation. Curr. Bioact. Comp., 11(3), 156–169. https://doi.org/10.2174/1573407211666150915214425
Pachauri, M., Gupta, E. D. & Ghosh, P. C. (2015). Piperine loaded PEG-PLGA
nanoparticles: Preparation, characterization and targeted delivery for adjuvant
breast cancer chemotherapy. J. Drug Del. Sci. Tech., 29, 269–282. https://doi.org/10.1016/j.jddst.2015.08.009
Elnaggar, Y. S. R. et al. (2015). Intranasal piperine-loaded chitosan nanoparticles
as brain-targeted therapy in alzheimer’s diesease: Optimization biological efficacy,
and potential toxicity. J. Pharm. Sci., 104(10), 3544–3556. https://doi.org/10.1002/jps.24557
Bhalekar, M. R. et al. (2017). Formulation of piperine solid lipid nanoparticles
(SLN) for treatment of rheumatoid arthritis. Drug Dev. Ind. Pharm., 43(6), 1003–
https://doi.org/10.1080/03639045.2017.1291666
Anissian, D. et al. (2017). Piperine-loaded chitosan-STPP nanoparticles reduce
neuronal loss and astrocytes activation in chemical kindling model of epilepsy. Int.
J. Biol. Macromol., 107, 973–983. https://doi.org/10.1016/j.ijbiomac.2017.09.073
Ramirez, Y. I. C. et al. (2018). The structural characteristics of starches and their
functional properties. J. Food, 16(1), 1003–1017. https://doi.org/10.1080/19476337.2018.1518343
Egharevba, H. O. (2019). Chemical properties of starch and its application in the
food industry. IntechOpen, 16–17. https://doi.org/10.5772/intechopen.87777
Kim, H. Y., Park, S. S. & Lim, S. T. (2014). Preparation and utilization of starch
nanoparticles. Coll. Surf. B Biointerf., 126, 607–620. https://doi.org/10.1016/j.colsurfb.2014.11.011
Pang, S. C. et al. (2015). Fabrication of polysaccharide-base nanoparticles
as drug delivery nanocarriers. ECS Trans., 66(37), 15–32. https://doi.org/10.1149/06637.0015ecst
Chin, S. F., Yazid, S. N. A & Pang, S. C. (2014). Preparation and characterization
of starch nanoparticles for controlled release of curcumin. Int. J. Polym. Sci.,
Article ID 340121. https://doi.org/10.1155/2014/340121
Pang, S. C., Tay, S. H. & Chin, S. F. (2014). Facile synthesis of curcumin-loaded
starch-maleate nanoparticles. J. Nanomater., Article ID 824025. https://doi.org/10.1155/2014/824025
Chin, S. F. et al. (2019). pH-responsive starch-citrate nanoparticles for controlled
release of paracetamol. Starch, 71(9–10), 1800336. https://doi.org/10.1002/star.201800336
Chin, S. F., Azman, A. & Pang, S. C. (2014). Size controlled synthesis of starch
nanoparticles by microemulsion method. J. Nanomater., Article ID 763736.
https://doi.org/10.1155/2014/763736
Michor, E. L. & Berg, J. C. (2015). Temperature effects on micelle formation and
particles charging with span surfactants in apolar media. Langm., 31, 9602–9607.
https://doi.org/10.1021/acs.langmuir.5b02711
Dutta, S. & Bhattacharjee P. (2017). Nanoliposomal encapsulates of piperine-
rich black pepper extract obtained by enzyme-assisted supercritical carbon
dioxide extraction. J. Food Eng., 201, 49–56. https://doi.org/10.1016/j.jfoodeng.2017.01.006