CELL TARGETING IN ANTI-CANCER GENE THERAPY

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Mohd Azmi Mohd Lila
John Shia Kwong Siew
Hayati Zakaria
Suria Mohd Saad
Lim Shen Ni
Jafri Malin Abdullah

Abstract

Gene therapy is a promising approach towards cancer treatment. The main aim of the therapy is to destroy cancer cells, usually by apoptotic mechanisms, and preserving others. However, its application has been hindered by many factors including poor cellular uptake, non-specific cell targeting and undesirable interferences with other genes or gene products. A variety of strategies exist to improve cellular uptake efficiency of gene-based therapies. This paper highlights advancements in gene therapy research and its application in relation to anti-cancer treatment.

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How to Cite
1.
Mohd Azmi Mohd Lila, John Shia Kwong Siew, Hayati Zakaria, Suria Mohd Saad, Lim Shen Ni, Jafri Malin Abdullah. CELL TARGETING IN ANTI-CANCER GENE THERAPY. Malays J Med Sci [Internet]. 2026 Oct. 6 [cited 2026 Oct. 18];11(1):9-23. Available from: https://ejournal.usm.my/mjms/article/view/mjms_vol11-no1-2004_2
Section
Review Article