ANTITUMOUR-PROMOTING AND CYTOTOXIC CONSTITUENTS OF ETLINGERA ELATIOR

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Published: Jan 31, 2005
DOI: https://doi.org/10.21315/
Keywords:
Etlingera elatior, antitumour-promoting, EBV-EA, cytotoxic, CEM-SS, MCF-7

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Habsah M
Department of Chemistry, Faculty of Science and Technology, University College of Science and Technology Malaysia (KUSTEM), Mengabang Telipot, 21030 Kuala Terengganu, Terengganu, Malaysia.
Ali AM
Department of Biotechnology, Faculty of Food Science and Biotechnology, University Putra Malaysia, 43400 Serdang, Selangor.
Lajis NH
Phytomedicinal Laboratory, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Selangor.
Yap YH
Department of Chemistry, Faculty of Science and Environmental Study, University Putra Malaysia, 43400 Serdang, Selangor.
Kikuzaki H
Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, 3-3 138, Sugimoto, Sumiyoshi-ku, Osaka, Japan
Nakatani N
Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, 3-3- 138, Sugimoto, Sumiyoshi-ku, Osaka, Japan.

Abstract

Phytochemical studies on rhizome of Etlingera elatior have resulted in the isolation of 1,7-bis(4-hydroxyphenyl)-2,4,6-heptatrienone (1), demethoxycurcumin (2), 1,7- bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (3), 16-hydroxylabda-8(17),11,13-
trien-16,15-olide (4), stigmast-4-en-3-one (5), stigmast-4-ene-3,6-dione (6), stigmast4-en-6b-ol-3-one (7), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (8). 1 and 4 were new compounds. Compounds 5 and 7 displayed high antitumour-promoting activity. Ethyl acetate extract showed a very significant cytotoxic activity against CEM-SS and MCF-7 cell lines (4 µg/ml and 6.25 µg/ml respectively). The antitumour promoting activity was determined by EBV-EA assay and cytotoxic activity was determined by MTT assay.

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How to Cite
1.
Habsah M, Ali AM, Lajis NH, Yap YH, Kikuzaki H, Nakatani N. ANTITUMOUR-PROMOTING AND CYTOTOXIC CONSTITUENTS OF ETLINGERA ELATIOR. Malays J Med Sci [Internet]. 2005 Jan. 31 [cited 2026 Oct. 19];12(1):6-12. Available from: https://ejournal.usm.my/mjms/article/view/mjms_vol12-no1-2005_3
Issue
Vol. 12 No. 1 (2005)
Section
Review Article
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