Alpha Lipoid Acid Prevents Islet Cells Damage and Dyslipidemia in Streptozotocin-Induced Diabetic Rats

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Published: Jul 31, 2007
DOI: https://doi.org/10.21315/
Keywords:
Alpha lipoic acid, Diabetes mellitus, Islet cells, Hyperglycemia, Dyslipidemia

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Siti Balkis Budin
Biomedical Department, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur
Kwa Poi Kee
Biomedical Department, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur
Monica Yau Swee Eng
Biomedical Department, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur.
Khairul Osman
Biomedical Department, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur.
Mokhtar Abu Bakar
Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Selangor Malaysia.
Jamaludin Mohamed
Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Selangor Malaysia.

Abstract

In the present study, the effects of alpha lipoic acid (ALA) supplementation on glycemic control and lipid profile in streptozotocin (STZ)-induced diabetic rats have been evaluated. Sprague Dawley rats were divided into nondiabetic (NDM), diabetic without supplementation (No Suppl) and diabetic with ALA groups. ALA was orally administered once a day for 8 weeks with a dose of 100 mg/kg BW. Supplementation of ALA to STZ-induced rats prevented the severe damage to the islet cells of the pancreas and lowered the plasma glucose and glycated hemoglobin (HbA1c) levels. Supplementation of ALA also suppressed the increased of total cholesterol (TC), triglycerides and low density lipoprotein-cholesterol (LDL-C) levels in the plasma of diabetic rats as well as increased high density lipoproteincholesterol (HDL-C) levels. In conclusion, this study suggest that ALA may be effective in controlling glycemic status and improving dyslipidemia in streptozotocin-induced diabetic rats and has the potential in reducing cardiovascular complications due to diabetes mellitus.

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1.
Siti Balkis Budin, Kwa Poi Kee, Monica Yau Swee Eng, Khairul Osman, Mokhtar Abu Bakar, Jamaludin Mohamed. Alpha Lipoid Acid Prevents Islet Cells Damage and Dyslipidemia in Streptozotocin-Induced Diabetic Rats. Malays J Med Sci [Internet]. 2007 Jul. 31 [cited 2026 Oct. 22];14(2):47-53. Available from: https://ejournal.usm.my/mjms/article/view/mjms_vol14-no2-2007_8
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Vol. 14 No. 2 (2007)
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Original Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

References

Mohamad S, Taha A, Bamezai, RNK, Basir S, Baquer NZ. Lower dose of vanadate in combination with

trigonella restore altered carbohydrate metabolism and antioxidant status in alloxan-diabetic rats. Clinica Chimica Acta. 2004; 342: 105-114.

Ihara Y, Toyokumi S, Uchida K, Odaka H, Tanaka T, Ikeda H. Hyperglycemia causes oxidative stress in pancreatic beta cells of GK rats a model of type 2 diabetes. Diabetes. 1999; 48: 927-932.

Koo JR, Ni Z, Oviesi F, Vaziri ND. Antioxidant therapy potentiates antihypertensive action of insulin in diabetic rats. Clinical Experimental Hypertension. 2002; 24: 333-344.

Ravi K, Rajasekaran S, Subramanium S. Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. Food and Chemical Toxicology. 2005; 43: 1433-1439.

Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant a-lipoic acid. Free Radical Biology & Medicine. 1997; 22: 359–378.

Packer L., Kreamer K. and Rimbach G. Molecular aspect of lipoic acid in the prevention of diabetes

complications. Nutrition. 2001; 17: 888-895.

Eross J, Kreutzmann D, Jimenez M, Keen R, Roger S, Cowell C, Vines R, Silink M. Colometric measurement

of glycosylated protein in whole blood, red blood cells, plasma and dried blood. Annal Clinical Biochemistry.

; 21: 477-483.

Friedewald WT, Levy RI, Fredicson DS. Estimation of the concentration of low density lipoprotein in

plasma without use of preparative ultracentrifuge. Clinical Chemistry1972; 28: 499-502.

Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Futani Y, Umayahara Y. Beneficial effects of

antioxidant in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.Diabetes.

; 48: 2398-2406.

Bynes JW, Thorpe SR, The role of oxidative stress in diabetic complications. Current Opinion in

Endocrinology. 1996; 3: 277-284.

Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavanoid antioxidant, prevents and protects streptozotocin-induces oxidative stress and -cells damage in rats pancreas. Pharmacological Research.

; 51: 117-123.

Kocak, G., Aftan, F., Elberg, S., Yildizoglu,-Ari, N. & Karasu, C. 2000. Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vassel alredy damaged by streptozotocin –diabetic rats. Diabetes Nutrition and Metabolism. 13: 308-318.

Szkudelski T, The mechanism of alloxan and streptozotocin action in -cells of the rat pancreas.

Physiology Research. 2001; 50: 537-546.

Vessal M, Hemmati M, Vasie M. Antidiabetic effects of quercetinin in streptozotocin-induced diabetic rats. Comparative Biochemistry and Physiology Toxicology & Pharmacology. 2003; 93: 189-200.

Thirunavukkarasu, V., Anita Nandhini, A.T. & Arunadha, C.Y. 2004. Effects of alpha lipoic acids on lipid profile in rats fed a high-fructose diet.

Experimental Diabetisity Research 5(3): 195-200. Lopes-Virella MF, Whitmann HJ, Mayfield PK, Loadhott CB, Colwell JA. Effects of metabolic control on lipid, lipoprotein and apolipoprotein levels in 55 insulin-dependent diabetic patients: a longitudinal study. Diabetes. 1983; 32: 20-25.

Kondo A, Muranaka Y, Ohta I, Notsu K, Manabe M, Kotani K, saito K, Mackawa M, Kanno T. Relationship between triglycerides concentrations and LDL sized evaluated by malondialdehyde-modified LDL.Clinical Chemistry. 2001; 47: 893-900.