Telemetric EEG and the Rat: A Guide For Neuroscientists

Abstract

Animal models for seizures and epilepsy have played a fundamental role in advancing our understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have been instrumental in the discovery and preclinical development of novel antiepileptic drugs. Despite the successful development of various new antiepileptic drugs in recent decades, the search for new therapies with better efficacy and tolerability remains an important goal (1). The discovery and development of a new antiepileptic
drug relies heavily on the preclinical use of animal models to establish efficacy and safety prior to first trials in humans (2).