The efficacy of vigabatrin in tonic-clonic and absence epilepsy models in mice

Abstract

Vigabatrin acts by inhibiting irreversibly the enzyme GABA-transaminase in a dose dependent manner. This study look at the protective effect of vigabatrin against pentylenetetrazol and maximal electroshock induced seizure in mice. This paper also compares the effect of acute single dosing and multiple subchronic dosing of vigabatrin against the seizure models. It appears that vigabatrin does not protect the mice against pentylenetetrazole induced seizure but it does however protect them against maximal electroshock induced seizure after treatment with vigabatrin daily for one week at the dose of 50mg/ kg(P<0.05). There appears to be ceiling of effect above which it does not protect the animals from maximal electroshock induced seizure.