Multiple polypoid endometriosis: a rare complication following withdrawal of gonadotrophin releasing hormone (GnRH) agonist for severe endometriosis: A case report

Abstract

A 30-year-old female who initially had typical endometriosis treated according to the standard regimen later developed numerous highly vascular endometrial polypi on the vagina, cervix, ureter, serosal surfaces of the uterus, pouch of Douglas (POD) and other areas of pelvic peritoneum as well as the endometrium 8 months after withdrawal of the hormone treatment. We postulate that these polypi developed as a rebound phenomenon upon withdrawal of Zoladex, a gonadotropin releasing hormone (GnRH) agonist used for the disease. We believe this is the first report of rare complication following use of GnRH analogue.