Histometric Analysis of Prostate in Reserpinized Albino Mice

Abstract

As the effect of reserpine on prostate has not yet been studied, this experiment was done to see the effect of 2 mg/kg of body weight of reserpine administered intraperitoneally for 7 days on the volume of stroma and secretory epithelium along with the height of the epithelium of the ventral & dorsolateral prostate. In the control group the same volume of saline was administered intraperitoneally for the same number of days. In the experimental group there were significant increase in the volume of stroma and secretory epithelium along with height of the secretory epithelium of the dorsolateral prostate, but in the ventral prostate there was no significant changes. The changes in the dorsolateral prostate of the experimental group may be due to increased plasma level of ACTH which stimulates the zona reticularis of the adrenal cortex to secrete androgens; then androgens stimulates the dorsolateral prostate. Ventral prostate of them experimental group showed no changes, the reason of which is still unknown and regarding which research scope is still wide open.