Mapping Global Research on Depression Among Medical Students: A Bibliometric and Conceptual Analysis (2001–2025)
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Abstract
Background: The importance of mental health among medical students has gained worldwide recognition, especially after the COVID-19 pandemic in 2019. High rates of depression among medical students have drawn the attention of researchers, who have sought to identify and explore the factors related to the onset of depression. This study conducted a comprehensive review of the literature on depression among medical students and developed a conceptual framework highlighting the interaction of various factors contributing to the onset and maintenance of depression.
Methods: This study conducted a bibliometric analysis of 467 papers retrieved from the Scopus database between 2001 and 2025. The eligibility criterion was articles that contained the terms “depression” and “medical students” in their titles. This systematic approach ensured a manageable dataset for analysis. Microsoft Excel and VOSviewer were used for an in-depth analysis of publication trends, affiliations, countries, prolific authors, and major journals and sources regarding depression among medical students.
Results: The highest number of papers published was in 2022, while the United States was identified as the most productive country. Co-occurrence analysis identified eight core themes: psychosocial factors, affective–cognitive factors, psychological stressors, coping mechanisms, burnout, mental health and well-being, academic performance, and lifestyle factors of depression among medical students.
Conclusion: This study significantly contributes to the field by constructing a comprehensive conceptual framework that logically organises thematic factors into predictors, moderators, and outcome variables, and is expected to guide future research and align with emerging trends in this domain. Additionally, this study highlights the need for global collaboration on many topics in this field and urges the development of suitable psychological preventive strategies to reduce the rate of depression among medical students.
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References
World Health Organization. Depressive disorder (depression) [Internet]. Geneva: World Health Organization; 2023 [Retrieved 2025 Jan 15]. Available at: https://www.who.int/news-room/fact-sheets/detail/depression
Stirparo G, Pireddu R, D’Angelo M, Bottignole D, Mazzoli R, Gambolò L. Is mental health worse in medical students than in the general population? A cross-sectional study. Medicina. 2024;60(6):863. https://doi.org/10.3390/medicina60060863
Quek TT, Tam WW, Tran BX, Zhang M, Zhang Z, Ho CS, et al. The global prevalence of anxiety among medical students: a meta-analysis. Int J Environ Res Public Health. 2019;16(15):2735. https://doi.org/10.3390/ijerph16152735
Rotenstein LS, Ramos MA, Torre M, Segal JB, Peluso MJ, Guille C, et al. Prevalence of depression, depressive symptoms, and suicidal ideation among medical students: a systematic review and meta-analysis. JAMA. 2016;316(21):2214–2236. https://doi.org/10.1001/jama.2016.17324
Sinval J, Oliveira P, Novais F, Almeida CM, Telles-Correia D. Exploring the impact of depression, anxiety, stress, academic engagement, and dropout intention on medical students’ academic performance: a prospective study. J Affect Disord. 2025;368:665–673. https://doi.org/10.1016/j.jad.2024.09.116
Saravanan C, Wilks R. Medical students’ experience of and reaction to stress: the role of depression and anxiety. ScientificWorldJournal. 2014;2014(1):737382. https://doi.org/10.1155/2014/737382
Puthran R, Zhang MW, Tam WW, Ho RC. Prevalence of depression amongst medical students: a meta-analysis. Med Educ. 2016;50(4):456–468. https://doi.org/10.1111/medu.12962
Bartolini M, Bottani E, Grosse EH. Green warehousing: systematic literature review and bibliometric analysis. J Clean Prod. 2019;226:242–258. https://doi.org/10.1016/j.jclepro.2019.04.055
Danvila-del-Valle I, Estévez-Mendoza C, Lara FJ. Human resources training: A bibliometric analysis. J Bus Res. 2019;101. https://doi.org/10.1016/j.jbusres.2019.02.026
Boudry C, Baudouin C, Mouriaux F. International publication trends in dry eye disease research: a bibliometric analysis. Ocul Surf. 2018;16(1):173–179. https://doi.org/10.1016/j.jtos.2017.10.002
Wang J, Zheng T, Wang Q, Xu B, Wang L. A bibliometric review of research trends on bioelectrochemical systems. Curr Sci. 2015;109(12):2204–2211. https://doi.org/10.18520/v109/i12/2204-2211
Van Eck NJ, Waltman L. VOSviewer manual [Internet]. Leiden: University of Leiden; 2019 [Retrieved 2025 Jan 22]. Available at: https://www.vosviewer.com/documentation/Manual_VOSviewer_1.6.13.pdf
Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: an overview and guidelines. J Bus Res. 2021;133:285–296. https://doi.org/10.1016/j.jbusres.2021.04.070
Aria M, Cuccurullo C. Bibliometrix: an R-tool for comprehensive science mapping analysis. J Informetr. 2017;11(4):959–975. https://doi.org/10.1016/j.joi.2017.08.007
Hassan S, Ahmi A. Mapping the state of the art of scientific production on requirements engineering research: a bibliometric analysis. Int J Inf Technol Syst Approach. 2022;15(1):1–23. https://doi.org/10.4018/IJITSA.289999
Razalli MR, Rahim MKI, Noordin A, Kafi A, Lateh A, Yusuf MF, et al. Global trends of circular economy and innovation research: a bibliometric analysis. Int J Sustain Dev Plan. 2024;19(12):4583–4594. https://doi.org/10.18280/ijsdp.191202
Vošner HB, Kokol P, Bobek S, Železnik D, Završnik J. A bibliometric retrospective of the Journal Computers in Human Behavior (1991–2015). Comput Human Behav. 2016;65:46–58. https://doi.org/10.1016/j.chb.2016.08.026
Zhao Z, Hu B, Xu K, Jiang Y, Xu X, Liu Y. A quantitative analysis of artificial intelligence research in cervical cancer: a bibliometric approach utilizing CiteSpace and VOSviewer. Front Oncol. 2024;14:1431142. https://doi.org/10.3389/fonc.2024.1431142
Remes O, Mendes JF, Templeton P. Biological, psychological, and social determinants of depression: a review of recent literature. Brain Sci. 2021;11(12):1633. https://doi.org/10.3390/brainsci11121633
Zhang X, Yue H, Sun J, Liu M, Li C, Bao H. Regulatory emotional self-efficacy and psychological distress among medical students: multiple mediating roles of interpersonal adaptation and self-acceptance. BMC Med Educ. 2022;22(1):283. https://doi.org/10.1186/s12909-022-03338-2
Ranasinghe PD, Owusu JT, Bertram A, Michtalik H, Yeh HC, Cofrancesco J Jr, et al. Depressive symptoms and burnout among medical students: a prospective study. J Gen Intern Med. 2022;37(1):64–69. https://doi.org/10.1007/s11606-021-06765-x
Younes F, Halawi G, Jabbour H, El Osta N, Karam L, Hajj A, et al. Internet addiction and relationships with insomnia, anxiety, depression, stress and self-esteem in university students: a cross-sectional designed study. PLoS One. 2016;11(9):e0161126. https://doi.org/10.1371/journal.pone.0161126
Alimoradi Z, Lin CY, Broström A, Bülow PH, Bajalan Z, Griffiths MD, et al. Internet addiction and sleep problems: a systematic review and meta-analysis. Sleep Med Rev. 2019;47:51–61. https://doi.org/10.1016/j.smrv.2019.06.004
Mofatteh M. Risk factors associated with stress, anxiety, and depression among university undergraduate students. AIMS Public Health. 2020;8(1):36–65. https://doi.org/10.3934/publichealth.2021004
Ramadianto AS, Kusumadewi I, Agiananda F, Raharjanti NW. Symptoms of depression and anxiety in Indonesian medical students: association with coping strategy and resilience. BMC Psychiatry. 2022;22(1):92. https://doi.org/10.1186/s12888-022-03745-1
Melaku L, Bulcha G, Worku D. Stress, anxiety, and depression among medical undergraduate students and their coping strategies. Educ Res Int. 2021;2021(1):9880309. https://doi.org/10.1155/2021/9880309
Healy C, Ryan Á, Moran CN, Harkin DW, Doyle F, Hickey A. Medical students, mental health and the role of resilience – a cross-sectional study. Med Teach. 2023;45(1):40–48. https://doi.org/10.1080/0142159X.2022.2128735
Shiraly R, Roshanfekr A, Asadollahi A, Griffiths MD. Psychological distress, social media use, and academic performance of medical students: the mediating role of coping style. BMC Med Educ. 2024;24(1):999. https://doi.org/10.1186/s12909-024-05988-w
Paudel K, Adhikari TB, Khanal P, Bhatta R, Paudel R, Bhusal S, et al. Sleep quality and its correlates among undergraduate medical students in Nepal: a cross-sectional study. PLOS Glob Public Health. 2022;2(2):e0000012. https://doi.org/10.1371/journal.pgph.0000012
Maslach C, Leiter MP. Understanding the burnout experience: recent research and its implications for psychiatry. World Psychiatry. 2016;15(2):103–111. https://doi.org/10.1002/wps.20311
Cairns P, Isham AE, Zachariae R. The association between empathy and burnout in medical students: a systematic review and meta-analysis. BMC Med Educ. 2024;24(1):640. https://doi.org/10.1186/s12909-024-05625-6
Ibrahim N, Al-Kharboush D, El-Khatib L, Al-Habib A, Asali D. Prevalence and predictors of anxiety and depression among female medical students in King Abdulaziz University, Jeddah, Saudi Arabia. Iran J Public Health. 2013;42(7):726–736.
Yusoff MSB, Abdul Rahim AF, Baba AA, Ismail SB, Mat Pa MN, Esa AR. Prevalence and associated factors of stress, anxiety and depression among prospective medical students. Asian J Psychiatr. 2013;6(2):128–133. https://doi.org/10.1016/j.ajp.2012.09.012
He X, Chen S, Zhang Q, He S, Yang L, Ma J. Mental health literacy and professional psychological help-seeking attitudes among primary healthcare workers: the mediating role of social support and mental illness stigma. Risk Manag Healthc Policy. 2025;18:703–718. https://doi.org/10.2147/RMHP.S512458
Li HY, Cao H, Leung DYP, Mak YW. The psychological impacts of a COVID-19 outbreak on college students in China: a longitudinal study. Int J Environ Res Public Health. 2020;17(11):3933. https://doi.org/10.3390/ijerph17113933
Saraswathi I, Saikarthik J, Senthil Kumar K, Madhan Srinivasan K, Ardhanaari M, Gunapriya R. Impact of COVID-19 outbreak on the mental health status of undergraduate medical students in a COVID-19 treating medical college: a prospective longitudinal study. PeerJ. 2020;8:e10164. https://doi.org/10.7717/peerj.10164
Dyrbye LN, Thomas MR, Huschka MM, Lawson KL, Novotny PJ, Sloan JA, et al. A multicenter study of burnout, depression, and quality of life in minority and nonminority US medical students. Mayo Clin Proc. 2006;81(11):1435–1442. https://doi.org/10.4065/81.11.1435
Seo C, Corrado M, Fournier K, Bailey T, Haykal KA. Addressing the physician burnout epidemic with resilience curricula in medical education: a systematic review. BMC Med Educ. 2021;21(1):80. https://doi.org/10.1186/s12909-021-02495-0