New Endiandric Acid from Beilschmiedia lumutensis and Their Molecular Docking Study as a-amylase and a-glucosidase Inhibitors (Early view)

Abstract

A preliminary study showed that an ethyl acetate extract of the bark from Beilschmiedia lumutensis (Lauraceae family) exhibited promising inhibition activities against ?-amylase and ?-glucosidase by in vitro assays. Subsequently, this extract revealed three new cyclic polyketides endiandric acids, namely lumutensic acid A-C (1-3). Their structures were elucidated by 1D and 2D NMR, FT-IR, HRESIMS spectroscopic data analysis and by comparison with literature data. The molecular docking study showed that lumutensic acid C (3) showed the highest binding affinity and stability with both enzymes, with strong hydrogen bonding and hydrophobic interactions, outperfoming the standard drug acarbose. These findings suggest that compound 3 could be a promising candidate for anti-hyperglycemic therapeutic development, providing further insight into the potential of B. lumutensis as a source of bioactive compounds.